Elderly and young: who is better protected after suffering coronavirus?

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Elderly and young: who is better protected after suffering coronavirus?

Elderly and young: who is better protected after suffering coronavirus?

Petersburg scientists came to the conclusion that in patients 60 – 70 years old after suffering coronavirus, antibodies are formed twice as much as in young people, and not only age, but also gender affects the time of the formation of the immune response. The details of the study, organized by the Kirov Military Medical Academy and the Helix laboratory service, were told to the MIR 24 TV channel by the doctor-immunologist Vladimir Bolibok.

– In the course of the study, we analyzed the data of more than one and a half thousand patients from 20 regions of Russia who suffered a severe or mild coronavirus. It turned out that the titer of antibodies is higher in those who are older. What is the reason for this?

Vladimir Bolibok: This is due to the fact that young people have a much higher level of cellular immunity. We do not test cellular immunity – it is very expensive, and we do not see or monitor this component of the immune system. And in old age, the immune system prefers to produce more antibodies, and we see these results in laboratory tests. The flip side of the coin, that in old age more antibodies are produced, is that they get sick more severely in old age precisely for the reason that when the virus clashes with antibodies in the lung tissue about a few days after the onset of the disease, this leads to the development of cytokine storm, and all the consequences are known.

Elderly and young: who is better protected after suffering coronavirus?

Elderly and young: who is better protected after suffering coronavirus?

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    Elderly and young: who is better protected after suffering coronavirus?

    Elderly and young: who is better protected after suffering coronavirus?

    FOLLOWING

    – Less than 1% of study participants aged 18 to 44 were found to be free of antibodies after illness. In older age groups, even those who had asymptomatic disease had antibodies. Can we assume that the human immune system develops and improves throughout life? Is it possible that most people have already encountered other similar diseases?

    Vladimir Bolibok: This suggests that those people who recovered from covid and they do not have antibodies, they coped due to purely cellular immunity, they did not need antibodies. The production of antibodies indicates that the disease has not passed completely without a trace for the immune system, and a trace in the form of antibodies remains.

    They do not have a very high-quality sample, because this was not a special study, but a study based on the data obtained as a result of hospitalizations and hospitalization tracking. If we take the outpatient link, then there are the number of antibodies in asymptomatic carriers and the number in those who suffered with symptoms, there are different ratios.

    – In men, the highest concentration of antibodies was determined on the 45th day of the study, and then decreased, while in women the indicator continued to increase until the 180th day of the study. How can this be explained?

    Vladimir Bolibok: This is a well-known fact: the female body, as a rule, produces much more antibodies than the male. This is the influence of sex hormones and the fact that the female body produces antibodies not only for itself, but also in order to transfer its immunity to the developing fetus during pregnancy.

    The flip side of the coin is that women are more likely to suffer from autoimmune diseases, they are more likely to have a failure in the synthesis of antibodies, and the immune system begins to attack its own tissues through antibodies.

    – Scientists have found that from the 45th to the 90th day after recovery, an unusually high titer of antibodies is recorded in women over 60 years old, even if a person has suffered a mild coronavirus infection. Is this due to the same?

    Vladimir Bolibok: Yes, the natural mechanism works in favor of women who live longer than men.

    – This study only concerned those who had a coronavirus infection. Can the same results be transferred to those who have been vaccinated?

    Vladimir Bolibok: Yes, there are such data, too, and all researchers note that the female body also responds better to vaccines – higher antibody titers after vaccination, and these titers last longer.

    – Was the female body stronger? And cellular immunity at age does not work as well as in young people, and is this compensation inside the body?

    Vladimir Bolibok: Yes, that's right. The younger the body, the higher cellular immunity, fewer antibodies are required to defeat the disease. The same goes for the difference between women and men. The nature of women generally protects better, because they are the continuers of the clan.

    – Scientists noticed that all participants in the study retain antibodies for at least three months, and those who were seriously ill, the elderly, even more than six months. Why does the antibody titer remain high after vaccination even after six months?

    Vladimir Bolibok: This is why vaccination is usually done in two doses, so that there is a longer contact with the vaccine material and so that the titer remains as long as possible. Revaccination is done with the aim of increasing the titer again and keeping it even longer.

    – Do you support vaccination six months after the primary vaccination?

    Vladimir Bolibok: I support both vaccination and revaccination precisely for the reason that, unfortunately, we have had a change of strain, and only a sufficiently high titer of antibodies and sufficiently good cellular immunity can protect against a new strain. We never know whether new strains will appear in the future or not. But, the higher the titer on old strains, the more reliably a person will be protected from new strains.

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